[HTML][HTML] Induction of smooth muscle α-actin in vascular smooth muscle cells by arginine vasopressin is mediated by c-Jun amino-terminal kinases and p38 mitogen …
C Garat, V Van Putten, ZA Refaat, C Dessev… - Journal of Biological …, 2000 - ASBMB
Exposure of vascular smooth muscle cells to arginine vasopressin (AVP) increases smooth
muscle α-actin (SM-α-actin) expression through activation of the SM-α-actin promoter. The
goal of this study was to determine the role of the mitogen-activated protein kinase (MAP
kinase) family in regulation of SM-α-actin expression. AVP activated all three MAP kinase
family members: ERKs, JNKs, and p38 MAP kinase. Inhibition of JNKs or p38 decreased
AVP-stimulated SM-α-actin promoter activity, whereas inhibition of ERKs had no effect. A …
muscle α-actin (SM-α-actin) expression through activation of the SM-α-actin promoter. The
goal of this study was to determine the role of the mitogen-activated protein kinase (MAP
kinase) family in regulation of SM-α-actin expression. AVP activated all three MAP kinase
family members: ERKs, JNKs, and p38 MAP kinase. Inhibition of JNKs or p38 decreased
AVP-stimulated SM-α-actin promoter activity, whereas inhibition of ERKs had no effect. A …