Importance Fluoroquinolones are among the most commonly prescribed antibiotics. Recent
clinical studies indicated an association between fluoroquinolone use and increased risk of
aortic aneurysm and dissection (AAD). This alarming association has raised concern,
especially in patients with AAD with risk of rupture and in individuals at risk for developing
AAD. Objective To examine the effect of ciprofloxacin on AAD development in mice. Design,
Setting, and Participants In a mouse model of moderate, sporadic AAD, 4-week-old male …