IL-17F promotes tissue injury in autoimmune kidney diseases
JH Riedel, HJ Paust, S Krohn, JE Turner… - Journal of the …, 2016 - journals.lww.com
The TH 17 immune response has a central role in the pathogenesis of autoimmune
diseases, implicating the TH 17 master cytokine, IL-17A, as the critical mediator of diseases
such as human and experimental crescentic GN. However, the relative importance of
additional TH 17 effector cytokines, including IL-17F, in immune-mediated tissue injury
remains to be fully elucidated. Here, using a mouse model of acute crescentic GN
(nephrotoxic nephritis), we identified CD4+ T cells and γδ T cells as the major cellular …
diseases, implicating the TH 17 master cytokine, IL-17A, as the critical mediator of diseases
such as human and experimental crescentic GN. However, the relative importance of
additional TH 17 effector cytokines, including IL-17F, in immune-mediated tissue injury
remains to be fully elucidated. Here, using a mouse model of acute crescentic GN
(nephrotoxic nephritis), we identified CD4+ T cells and γδ T cells as the major cellular …
