B cell subsets differ in development, tissue distribution, and mechanisms of activation. In
response to infections, however, all can differentiate into extrafollicular plasmablasts that
rapidly provide highly protective antibodies, indicating that these plasmablasts are the main
humoral immune response effectors. Yet, the effectiveness of this response type depends on
the presence of antigen-specific precursors in the circulating mature B cell pool, a pool that
is generated initially through the stochastic processes of B cell receptor assembly …