Reactive cholangiocytes differentiate into proliferative hepatocytes with efficient DNA repair in mice with chronic liver injury
Background & Aim Chronic liver diseases are characterized by expansion of the small
immature cholangiocytes–a mechanism named ductular reaction (DR)–which have the
capacity to differentiate into hepatocytes. We investigated the kinetics of this differentiation,
as well as analyzing several important features of the newly formed hepatocytes, such as
functional maturity, clonal expansion and resistance to stress in mice with long-term liver
damage. Methods We tracked cholangiocytes using osteopontin-iCreER T2 and …
immature cholangiocytes–a mechanism named ductular reaction (DR)–which have the
capacity to differentiate into hepatocytes. We investigated the kinetics of this differentiation,
as well as analyzing several important features of the newly formed hepatocytes, such as
functional maturity, clonal expansion and resistance to stress in mice with long-term liver
damage. Methods We tracked cholangiocytes using osteopontin-iCreER T2 and …