Analysis of liver microenvironment during early progression of non-alcoholic fatty liver disease-associated hepatocellular carcinoma in zebrafish

C Michael, FJ Martinez-Navarro… - JoVE (Journal of Visualized …, 2021 - jove.com
Liver cancer is currently the third leading cause of cancer related death worldwide, and
Hepatocellular Carcinoma (HCC) accounts for 75-90% of all liver cancer cases. With the
introduction of effective treatments to prevent and treat hepatitis B/C, non-alcoholic fatty liver
disease (NAFLD), and the more aggressive form know as non-alcoholic steatohepatitis
(NASH), are quickly becoming the number one risk factors to develop HCC in modern
societies. To better understand the role NASH has on the development of HCC we designed …