A novel keratin18 promoter that drives reporter gene expression in the intrahepatic and extrahepatic biliary system allows isolation of cell-type specific transcripts from …
BJ Wilkins, W Gong, M Pack - Gene expression patterns, 2014 - Elsevier
Heritable and acquired biliary disorders are an important cause of acute and chronic human
liver disease. Biliary development and physiology have been studied extensively in rodent
models and more recently, zebrafish have been used to uncover pathogenic mechanisms
and potential therapies for these conditions. Here we report development of novel
transgenic lines labeling the intrahepatic and extrahepatic biliary system of zebrafish larvae
that can be used for lineage tracing and isolation of biliary-specific RNAs from mixed …
liver disease. Biliary development and physiology have been studied extensively in rodent
models and more recently, zebrafish have been used to uncover pathogenic mechanisms
and potential therapies for these conditions. Here we report development of novel
transgenic lines labeling the intrahepatic and extrahepatic biliary system of zebrafish larvae
that can be used for lineage tracing and isolation of biliary-specific RNAs from mixed …