[PDF][PDF] The cellular basis for animal regeneration

EM Tanaka, PW Reddien - Developmental cell, 2011 - cell.com
EM Tanaka, PW Reddien
Developmental cell, 2011cell.com
The ability of animals to regenerate missing parts is a dramatic and poorly understood
aspect of biology. The sources of new cells for these regenerative phenomena have been
sought for decades. Recent advances involving cell fate tracking in complex tissues have
shed new light on the cellular underpinnings of regeneration in Hydra, planarians, zebrafish,
Xenopus, and Axolotl. Planarians accomplish regeneration with use of adult pluripotent stem
cells, whereas several vertebrates utilize a collection of lineage-restricted progenitors from …
The ability of animals to regenerate missing parts is a dramatic and poorly understood aspect of biology. The sources of new cells for these regenerative phenomena have been sought for decades. Recent advances involving cell fate tracking in complex tissues have shed new light on the cellular underpinnings of regeneration in Hydra, planarians, zebrafish, Xenopus, and Axolotl. Planarians accomplish regeneration with use of adult pluripotent stem cells, whereas several vertebrates utilize a collection of lineage-restricted progenitors from different tissues. Together, an array of cellular strategies—from pluripotent stem cells to tissue-specific stem cells and dedifferentiation—are utilized for regeneration.
cell.com