[HTML][HTML] Lysophospholipids induce innate immune transdifferentiation of endothelial cells, resulting in prolonged endothelial activation
Innate immune cells express danger-associated molecular pattern (DAMP) receptors, T-cell
costimulation/coinhibition receptors, and major histocompatibility complex II (MHC-II). We
have recently proposed that endothelial cells can serve as innate immune cells, but the
molecular mechanisms involved still await discovery. Here, we investigated whether human
aortic endothelial cells (HAECs) could be transdifferentiated into innate immune cells by
exposing them to hyperlipidemia–up-regulated DAMP molecules, ie lysophospholipids …
costimulation/coinhibition receptors, and major histocompatibility complex II (MHC-II). We
have recently proposed that endothelial cells can serve as innate immune cells, but the
molecular mechanisms involved still await discovery. Here, we investigated whether human
aortic endothelial cells (HAECs) could be transdifferentiated into innate immune cells by
exposing them to hyperlipidemia–up-regulated DAMP molecules, ie lysophospholipids …