Serum trimethylamine-N-oxide is elevated in CKD and correlates with coronary atherosclerosis burden
JR Stubbs, JA House, AJ Ocque, S Zhang… - Journal of the …, 2016 - journals.lww.com
Abstract Trimethlyamine-N-oxide (TMAO) was recently identified as a promoter of
atherosclerosis. Patients with CKD exhibit accelerated development of atherosclerosis;
however, no studies have explored the relationship between TMAO and atherosclerosis
formation in this group. This study measured serum concentrations and urinary excretion of
TMAO in a CKD cohort (n= 104), identified the effect of renal transplant on serum TMAO
concentration in a subset of these patients (n= 6), and explored the cross-sectional …
atherosclerosis. Patients with CKD exhibit accelerated development of atherosclerosis;
however, no studies have explored the relationship between TMAO and atherosclerosis
formation in this group. This study measured serum concentrations and urinary excretion of
TMAO in a CKD cohort (n= 104), identified the effect of renal transplant on serum TMAO
concentration in a subset of these patients (n= 6), and explored the cross-sectional …