Vascular inflammation and atherogenesis are activated via receptors for PAMPs and suppressed by regulatory T cells

XF Yang, Y Yin, H Wang - Drug Discovery Today: Therapeutic Strategies, 2008 - Elsevier
Despite significant advances in identifying the risk factors and elucidating atherosclerotic
pathology, atherosclerosis remains the leading cause of morbidity and mortality in
industrialized society. These risk factors independently or synergistically lead to chronic
vascular inflammation, which is an essential requirement for the progression of
atherosclerosis in patients. However, the mechanisms underlying the pathogenic link
between the risk factors and the atherosclerotic inflammation remain poorly defined …