[HTML][HTML] Myc and ChREBP transcription factors cooperatively regulate normal and neoplastic hepatocyte proliferation in mice
H Wang, JM Dolezal, S Kulkarni, J Lu, J Mandel… - Journal of Biological …, 2018 - ASBMB
Analogous to the c-Myc (Myc)/Max family of bHLH-ZIP transcription factors, there exists a
parallel regulatory network of structurally and functionally related proteins with Myc-like
functions. Two related Myc-like paralogs, termed MondoA and MondoB/carbohydrate
response element–binding protein (ChREBP), up-regulate gene expression in
heterodimeric association with the bHLH-ZIP Max-like factor Mlx. Myc is necessary to
support liver cancer growth, but not for normal hepatocyte proliferation. Here, we …
parallel regulatory network of structurally and functionally related proteins with Myc-like
functions. Two related Myc-like paralogs, termed MondoA and MondoB/carbohydrate
response element–binding protein (ChREBP), up-regulate gene expression in
heterodimeric association with the bHLH-ZIP Max-like factor Mlx. Myc is necessary to
support liver cancer growth, but not for normal hepatocyte proliferation. Here, we …