[HTML][HTML] Hepatocyte growth factor preserves beta cell mass and mitigates hyperglycemia in streptozotocin-induced diabetic mice
C Dai, Y Li, J Yang, Y Liu - Journal of Biological Chemistry, 2003 - ASBMB
Type I diabetes is an autoimmune disease that results in destructive depletion of the insulin-
producing beta cells in the islets of Langerhans in pancreas. With the knowledge that
hepatocyte growth factor (HGF) is a potent survival factor for a wide variety of cells, we
hypothesized that supplementation of HGF may provide a novel strategy for protecting
pancreatic beta cells from destructive death and for preserving insulin production. In this
study, we demonstrate that expression of the exogenous HGF gene preserved insulin …
producing beta cells in the islets of Langerhans in pancreas. With the knowledge that
hepatocyte growth factor (HGF) is a potent survival factor for a wide variety of cells, we
hypothesized that supplementation of HGF may provide a novel strategy for protecting
pancreatic beta cells from destructive death and for preserving insulin production. In this
study, we demonstrate that expression of the exogenous HGF gene preserved insulin …