Molecular cloning and sequence analysis of the cDNA for a human serine protease reponsible for activation of hepatocyte growth factor. Structural similarity of the …
K Miyazawa, T Shimomura, A Kitamura, J Kondo… - Journal of Biological …, 1993 - ASBMB
Hepatocyte growth factor (HGF) is a potent mitogen for parenchymal liver cells, epithelial
cells, and endothelial cells and may play an important role in liver regeneration following
hepatic injury. HGF is homologous to plasminogen and is first synthesized and secreted as
an inactive single-chain precursor and then activated to a heterodimeric form by
endoproteolytic processing. Recently, a novel serine protease responsible for this
processing (HGF activator) has been purified from fetal bovine serum (Shimomura, T …
cells, and endothelial cells and may play an important role in liver regeneration following
hepatic injury. HGF is homologous to plasminogen and is first synthesized and secreted as
an inactive single-chain precursor and then activated to a heterodimeric form by
endoproteolytic processing. Recently, a novel serine protease responsible for this
processing (HGF activator) has been purified from fetal bovine serum (Shimomura, T …
