[HTML][HTML] Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice [S]

AG Linden, S Li, HY Choi, F Fang, M Fukasawa… - Journal of lipid …, 2018 - ASBMB
Lipogenesis in liver is highest in the postprandial state; insulin activates SREBP-1c, which
transcriptionally activates genes involved in FA synthesis, whereas glucose activates
carbohydrate-responsive element-binding protein (ChREBP), which activates both
glycolysis and FA synthesis. Whether SREBP-1c and ChREBP act independently of one
another is unknown. Here, we characterized mice with liver-specific deletion of ChREBP (L-
Chrebp−/− mice). Hepatic ChREBP deficiency resulted in reduced mRNA levels of glycolytic …