Interferon regulatory factor‐5 in resident macrophage promotes polycystic kidney disease
KA Zimmerman, J Huang, L He, DZ Revell, Z Li… - Kidney360, 2020 - journals.lww.com
Background Autosomal dominant polycystic kidney disease is caused by genetic mutations
in PKD1 or PKD2. Macrophages and their associated inflammatory cytokines promote cyst
progression; however, transcription factors within macrophages that control cytokine
production and cystic disease are unknown. Methods In these studies, we used conditional
Pkd1 mice to test the hypothesis that macrophage-localized interferon regulatory factor-5
(IRF5), a transcription factor associated with production of cyst-promoting cytokines (TNFα …
in PKD1 or PKD2. Macrophages and their associated inflammatory cytokines promote cyst
progression; however, transcription factors within macrophages that control cytokine
production and cystic disease are unknown. Methods In these studies, we used conditional
Pkd1 mice to test the hypothesis that macrophage-localized interferon regulatory factor-5
(IRF5), a transcription factor associated with production of cyst-promoting cytokines (TNFα …