[HTML][HTML] Regulation of kynurenine metabolism by a ketogenic diet
S Heischmann, LB Gano, K Quinn, LP Liang… - Journal of lipid …, 2018 - ASBMB
Ketogenic diets (KDs) are increasingly utilized as treatments for epilepsy, other neurological
diseases, and cancer. Despite their long history in suppressing seizures, the distinct
molecular mechanisms of action of KDs are still largely unknown. The goal of this study was
to identify key metabolites and pathways altered in the hippocampus and plasma of rats fed
a KD versus control diet (CD) either ad libitum or calorically restricted to 90% of the
recommended intake. This was accomplished using a combination of targeted methods and …
diseases, and cancer. Despite their long history in suppressing seizures, the distinct
molecular mechanisms of action of KDs are still largely unknown. The goal of this study was
to identify key metabolites and pathways altered in the hippocampus and plasma of rats fed
a KD versus control diet (CD) either ad libitum or calorically restricted to 90% of the
recommended intake. This was accomplished using a combination of targeted methods and …