Leptin regulates energy balance and motivation through action at distinct neural circuits
JF Davis, DL Choi, JD Schurdak, MF Fitzgerald… - Biological …, 2011 - Elsevier
BACKGROUND:: Overconsumption of calorically dense foods contributes substantially to the
current obesity epidemic. The adiposity hormone leptin has been identified as a potential
modulator of reward-induced feeding. The current study asked whether leptin signaling
within the lateral hypothalamus (LH) and midbrain is involved in effort-based responding for
food rewards and/or the modulation of mesolimbic dopamine. METHODS:: The contribution
of endogenous leptin signaling for food motivation and mesolimbic dopamine tone was …
current obesity epidemic. The adiposity hormone leptin has been identified as a potential
modulator of reward-induced feeding. The current study asked whether leptin signaling
within the lateral hypothalamus (LH) and midbrain is involved in effort-based responding for
food rewards and/or the modulation of mesolimbic dopamine. METHODS:: The contribution
of endogenous leptin signaling for food motivation and mesolimbic dopamine tone was …