A remarkable amount of information has emerged in the past decade regarding sweet taste
physiology. This article reviews these data, with a particular focus on the elucidation of the
sweet taste receptor, its location and actions in taste transduction in the mouth, its nontaste
functions in the gastrointestinal tract (eg, in enteroendocrine cells), and the brain circuitry
involved in the sensory processing of sweet taste. Complications in the use of rodents to
model human sweet taste perception and responses are also considered. In addition …