Wnt4/β− catenin signaling in medullary kidney myofibroblasts

DP DiRocco, A Kobayashi, MM Taketo… - Journal of the …, 2013 - journals.lww.com
Injury to the adult kidney induces a number of developmental genes thought to regulate
repair, including Wnt4. During kidney development, early nephron precursors and medullary
stroma both express Wnt4, where it regulates epithelialization and controls smooth muscle
fate, respectively. Expression patterns and roles for Wnt4 in the adult kidney, however,
remain unclear. In this study, we used reporters, lineage analysis, and conditional knockout
or activation of the Wnt/β-catenin pathway to investigate Wnt4 in the adult kidney …