Gli1+ pericyte loss induces capillary rarefaction and proximal tubular injury
R Kramann, J Wongboonsin… - Journal of the …, 2017 - journals.lww.com
Peritubular capillary rarefaction is hypothesized to contribute to the increased risk of future
CKD after AKI. Here, we directly tested the role of Gli1+ kidney pericytes in the maintenance
of peritubular capillary health, and the consequences of pericyte loss during injury. Using
bigenic Gli1-CreER t2; R26tdTomato reporter mice, we observed increased distance
between Gli1+ pericytes and endothelial cells after AKI (mean±SEM: 3.3±0.1 µm before
injury versus 12.5±0.2 µm after injury; P< 0.001). Using a genetic ablation model, we asked …
CKD after AKI. Here, we directly tested the role of Gli1+ kidney pericytes in the maintenance
of peritubular capillary health, and the consequences of pericyte loss during injury. Using
bigenic Gli1-CreER t2; R26tdTomato reporter mice, we observed increased distance
between Gli1+ pericytes and endothelial cells after AKI (mean±SEM: 3.3±0.1 µm before
injury versus 12.5±0.2 µm after injury; P< 0.001). Using a genetic ablation model, we asked …