Predominant IgG4 subclass in autoantibodies of pemphigus vulgaris and foliaceus
Y Futei, M Amagai, K Ishii, K Kuroda-Kinoshita… - Journal of …, 2001 - Elsevier
Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune skin diseases
caused by autoantibodies against desmoglein (Dsg) 3 and Dsg1. We have previously
developed ELISAs using recombinant Dsg3 and Dsg1 expressed by baculovirus as a
diagnostic tool for pemphigus. In this study, we determined the frequency of coexistence of
IgA class as well as distribution of IgG subclass. Two out of 49 PV and PF sera tested had
anti-Dsg1 IgA in addition to anti-Dsg1 IgG. Interestingly, one of them showed prominent …
caused by autoantibodies against desmoglein (Dsg) 3 and Dsg1. We have previously
developed ELISAs using recombinant Dsg3 and Dsg1 expressed by baculovirus as a
diagnostic tool for pemphigus. In this study, we determined the frequency of coexistence of
IgA class as well as distribution of IgG subclass. Two out of 49 PV and PF sera tested had
anti-Dsg1 IgA in addition to anti-Dsg1 IgG. Interestingly, one of them showed prominent …