The single-cell phenotypic identity of human CD8+ and CD4+ T cells
J Brummelman, K Pilipow, E Lugli - … review of cell and molecular biology, 2018 - Elsevier
On antigen encounter, naïve CD8+ and CD4+ T cells differentiate into a large number of
effector cells that migrate to inflamed tissues to fight infections or tumors. Following
elimination of the target, a few cells remain in the long-term, the so-called memory T cells
that are capable to reexpand and respond more vigorously on a second encounter with the
cognate antigen. While the naïve T cell compartment is fairly homogenous, effector and
memory T cells are largely diverse, comprising dozens of subsets with diverse functions …
effector cells that migrate to inflamed tissues to fight infections or tumors. Following
elimination of the target, a few cells remain in the long-term, the so-called memory T cells
that are capable to reexpand and respond more vigorously on a second encounter with the
cognate antigen. While the naïve T cell compartment is fairly homogenous, effector and
memory T cells are largely diverse, comprising dozens of subsets with diverse functions …