Current and future outlook on disease modification and defining low disease activity in systemic sclerosis

V Nagaraja, M Matucci‐Cerinic, DE Furst… - Arthritis & …, 2020 - Wiley Online Library
V Nagaraja, M Matucci‐Cerinic, DE Furst, M Kuwana, Y Allanore, CP Denton, G Raghu…
Arthritis & rheumatology, 2020Wiley Online Library
Systemic sclerosis (SS c) is an autoimmune rheumatic disease with heterogeneous clinical
manifestations and a variable course in which the severity of the pathology dictates the
disease prognosis and course. Among autoimmune rheumatic diseases, SS c has the
highest mortality rate among all rheumatic diseases, though there are exciting new
therapeutic targets that appear to halt the progression of SS c manifestations such as skin or
lung fibrosis. In selected patients, high‐intensity regimens with autologous stem cell …
Systemic sclerosis (SSc) is an autoimmune rheumatic disease with heterogeneous clinical manifestations and a variable course in which the severity of the pathology dictates the disease prognosis and course. Among autoimmune rheumatic diseases, SSc has the highest mortality rate among all rheumatic diseases, though there are exciting new therapeutic targets that appear to halt the progression of SSc manifestations such as skin or lung fibrosis. In selected patients, high‐intensity regimens with autologous stem cell transplantation can favorably modify the course. In what was once thought to be an untreatable disease, targeted therapies have now changed the outlook of SSc to a treatable disorder. Herein, we discuss the targeted therapies modifying the outlook on selected organ involvement and creating opportunities for future treatment. We also present a framework for defining low disease activity in SSc.
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