[HTML][HTML] Receptor tyrosine kinases, TYRO3, AXL, and MER, demonstrate distinct patterns and complex regulation of ligand-induced activation
WI Tsou, KQN Nguyen, DA Calarese… - Journal of Biological …, 2014 - ASBMB
TYRO3, AXL, and MER receptors (TAMs) are three homologous type I receptor-tyrosine
kinases that are activated by endogenous ligands, protein S (PROS1) and growth arrest-
specific gene 6 (GAS6). These ligands can either activate TAMs as soluble factors, or, in
turn, opsonize phosphatidylserine (PS) on apoptotic cells (ACs) and serve as bridging
molecules between ACs and TAMs. Abnormal expression and activation of TAMs have been
implicated in promoting proliferation and survival of cancer cells, as well as in suppressing …
kinases that are activated by endogenous ligands, protein S (PROS1) and growth arrest-
specific gene 6 (GAS6). These ligands can either activate TAMs as soluble factors, or, in
turn, opsonize phosphatidylserine (PS) on apoptotic cells (ACs) and serve as bridging
molecules between ACs and TAMs. Abnormal expression and activation of TAMs have been
implicated in promoting proliferation and survival of cancer cells, as well as in suppressing …