[HTML][HTML] FXR regulates organic solute transporters α and β in the adrenal gland, kidney, and intestine
H Lee, Y Zhang, FY Lee, SF Nelson, FJ Gonzalez… - Journal of lipid …, 2006 - ASBMB
Expression of the farnesoid X receptor (FXR; NR1H4) is limited to the liver, intestine, kidney,
and adrenal gland. However, the role of FXR in the latter two organs is unknown. In the
current study, we performed microarray analysis using RNA from H295R cells infected with
constitutively active FXR. Several putative FXR target genes were identified, including the
organic solute transporters α and β (OSTα and OSTβ). Electromobility shift assays and
promoter-reporter studies identified functional farnesoid X receptor response elements …
and adrenal gland. However, the role of FXR in the latter two organs is unknown. In the
current study, we performed microarray analysis using RNA from H295R cells infected with
constitutively active FXR. Several putative FXR target genes were identified, including the
organic solute transporters α and β (OSTα and OSTβ). Electromobility shift assays and
promoter-reporter studies identified functional farnesoid X receptor response elements …