Effect of therapeutic levels of doxycycline and minocycline in the proliferation and differentiation of human bone marrow osteoblastic cells
PS Gomes, MH Fernandes - Archives of oral biology, 2007 - Elsevier
Semi-synthetic tetracyclines (TCs) have been reported to reduce pathological bone
resorption through several mechanisms, although their effect over bone physiological
metabolism is not yet fully understood. The present study aims at evaluate the behaviour of
osteoblastic-induced human bone marrow cells regarding proliferation and functional
activity, in the presence of representative therapeutic concentrations of doxycycline and
minocycline. First passage human osteoblastic bone marrow cells were cultured for 35 days …
resorption through several mechanisms, although their effect over bone physiological
metabolism is not yet fully understood. The present study aims at evaluate the behaviour of
osteoblastic-induced human bone marrow cells regarding proliferation and functional
activity, in the presence of representative therapeutic concentrations of doxycycline and
minocycline. First passage human osteoblastic bone marrow cells were cultured for 35 days …