The influence of orally-administered penicillin upon growth and liver thiamine of growing germfree and normal stock rats fed a thiamine-deficient diet

BS Wostmann, PL Knight, JA Reyniers - The Journal of Nutrition, 1958 - Elsevier
Procaine penicillin G (50 mg/kg diet) was administered to young germfree and normal stock
rats on a thiamine-deficient diet. Normal stock rats showed continued, though retarded
growth, while the untreated controls started to lose weight after two weeks. In rats sacrificed
after 4 weeks the thiamine content of the liver was 0.50 µg/gm in the untreated group, 1.16 in
the treated group and 8.57 in animals receiving a complete diet. All untreated rats not
sacrificed at that time died between the 6th and 10th weeks. Germfree animals showed no …