Suppressive effects of minocycline on the pituitary-thyroid axis in humans
T Shigematsu, F Matsumoto, T Imai, I Sakurai… - Journal of Infection and …, 1995 - Elsevier
Minocycline has been thought to induce “black thyroid,” a condition marked by discoloration
due to brown deposits. However, its effect on thyroid function in humans is still obscure. We
conducted a prospective study of thyroid hormone levels in 17 patients who were
administered 200 mg minocycline daily for 10 days. We found that minocycline significantly
reduced the serum total thyroxine level (8.43±0.61 to 7.09±0.45 μg/dl, mean±SEM; P< 0.01),
and free thyroxine level (1.12±0.10 to 1.01±0.08 ng/dl, mean±SEM; P< 0.01). There was …
due to brown deposits. However, its effect on thyroid function in humans is still obscure. We
conducted a prospective study of thyroid hormone levels in 17 patients who were
administered 200 mg minocycline daily for 10 days. We found that minocycline significantly
reduced the serum total thyroxine level (8.43±0.61 to 7.09±0.45 μg/dl, mean±SEM; P< 0.01),
and free thyroxine level (1.12±0.10 to 1.01±0.08 ng/dl, mean±SEM; P< 0.01). There was …