Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, phosphatidylinositol 3'-kinase, and protein kinase C.
NS Yee, CW Hsiau, H Serve, K Vosseller… - Journal of Biological …, 1994 - ASBMB
The receptor tyrosine kinase Kit and Kit ligand (KL), encoded at the murine white spotting
(W) and steel (Sl) loci, respectively, function in hematopoiesis, melanogenesis, and
gametogenesis. To understand the mechanism of turnover of Kit in mast cells, mutant
receptors generated in vitro were heterologously expressed in Wsb/Wsh mast cells lacking
endogenous c-kit expression, and the effects of mutations on KL-induced internalization and
ubiquitination/degradation of Kit were studied. Upon binding of KL, KL. Kit receptor …
(W) and steel (Sl) loci, respectively, function in hematopoiesis, melanogenesis, and
gametogenesis. To understand the mechanism of turnover of Kit in mast cells, mutant
receptors generated in vitro were heterologously expressed in Wsb/Wsh mast cells lacking
endogenous c-kit expression, and the effects of mutations on KL-induced internalization and
ubiquitination/degradation of Kit were studied. Upon binding of KL, KL. Kit receptor …