[HTML][HTML] Sonic hedgehog maintains survival and growth of chronic myeloid leukemia progenitor cells through β-catenin signaling
W Su, F Meng, L Huang, M Zheng, W Liu… - Experimental hematology, 2012 - Elsevier
Sonic hedgehog (Shh) signaling plays an important role in many human cancers and cancer
stem cells. Here we investigate the activity and functional role of Shh signaling in chronic
myeloid leukemia (CML) and leukemia progenitor cells. Differential activation of Shh
signaling was found in about 50% CML chronic phase samples, about 70% of CML
accelerated phase samples, and> 80% CML blast crisis phase samples. Deregulated
activation of Shh signaling was observed in CD34+ and c-kit+ leukemia progenitor cells …
stem cells. Here we investigate the activity and functional role of Shh signaling in chronic
myeloid leukemia (CML) and leukemia progenitor cells. Differential activation of Shh
signaling was found in about 50% CML chronic phase samples, about 70% of CML
accelerated phase samples, and> 80% CML blast crisis phase samples. Deregulated
activation of Shh signaling was observed in CD34+ and c-kit+ leukemia progenitor cells …