[HTML][HTML] IL-36γ is a crucial proximal component of protective type-1-mediated lung mucosal immunity in Gram-positive and-negative bacterial pneumonia
MA Kovach, B Singer, G Martinez-Colon… - Mucosal …, 2017 - Elsevier
Abstract Interleukin-36γ (IL-36γ) is a member of novel IL-1-like proinflammatory cytokine
family that are highly expressed in epithelial tissues and several myeloid-derived cell types.
Little is known about the role of the IL-36 family in mucosal immunity, including lung anti-
bacterial responses. We used murine models of IL-36γ deficiency to assess the contribution
of IL-36γ in the lung during experimental pneumonia. Induction of IL-36γ was observed in
the lung in response to Streptococcus pneumoniae (Sp) infection, and mature IL-36γ protein …
family that are highly expressed in epithelial tissues and several myeloid-derived cell types.
Little is known about the role of the IL-36 family in mucosal immunity, including lung anti-
bacterial responses. We used murine models of IL-36γ deficiency to assess the contribution
of IL-36γ in the lung during experimental pneumonia. Induction of IL-36γ was observed in
the lung in response to Streptococcus pneumoniae (Sp) infection, and mature IL-36γ protein …
