OxLDL-dependent activation of arginase II is dependent on the LOX-1 receptor and downstream RhoA signaling
S Ryoo, A Bhunia, F Chang, A Shoukas, DE Berkowitz… - Atherosclerosis, 2011 - Elsevier
AIMS: Arginase II regulates NOS activity by competing for the substrate l-arginine. Oxidized
LDL (OxLDL) is a proatherogenic molecule that activates arginase II. We tested the
hypotheses that OxLDL-dependent arginase II activation occurs through a specific receptor,
and via a Rho GTPase effector mechanism that is inhibited by statins. METHODS AND
RESULTS: Arginase II activation by OxLDL was attenuated following preincubation with the
LOX-1 receptor-blocking antibody JTX92. This also prevented the dissociation of arginase II …
LDL (OxLDL) is a proatherogenic molecule that activates arginase II. We tested the
hypotheses that OxLDL-dependent arginase II activation occurs through a specific receptor,
and via a Rho GTPase effector mechanism that is inhibited by statins. METHODS AND
RESULTS: Arginase II activation by OxLDL was attenuated following preincubation with the
LOX-1 receptor-blocking antibody JTX92. This also prevented the dissociation of arginase II …
