[HTML][HTML] MERTK tyrosine kinase receptor together with TIM4 phosphatidylserine receptor mediates distinct signal transduction pathways for efferocytosis and cell …
C Nishi, Y Yanagihashi, K Segawa, S Nagata - Journal of Biological …, 2019 - ASBMB
Apoptotic cells expose phosphatidylserine (PtdSer) on their surface, leading to efferocytosis,
ie their engulfment by resident macrophages that express the PtdSer receptor T cell
immunoglobulin mucin receptor 4 (TIM4) and TAM family receptor tyrosine kinase receptors
(MERTK, AXL, and TYRO3). TAM family receptors stimulate cell proliferation, and the many
aspects of the growth signaling pathway downstream of TAM family receptors have been
elucidated previously. However, the signaling cascade for TAM receptor–mediated …
ie their engulfment by resident macrophages that express the PtdSer receptor T cell
immunoglobulin mucin receptor 4 (TIM4) and TAM family receptor tyrosine kinase receptors
(MERTK, AXL, and TYRO3). TAM family receptors stimulate cell proliferation, and the many
aspects of the growth signaling pathway downstream of TAM family receptors have been
elucidated previously. However, the signaling cascade for TAM receptor–mediated …
