Integrating the roles of liver X receptors in inflammation and infection: mechanisms and outcomes
E Glaría, NA Letelier, AF Valledor - Current Opinion in Pharmacology, 2020 - Elsevier
Liver X receptors (LXRs) are transcription factors from the nuclear receptor family that can be
pharmacologically activated by high-affinity agonists. LXR activation exerts a combination of
metabolic and anti-inflammatory actions that result in the modulation of immune responses
and in the amelioration of inflammatory disorders. In addition, LXR agonists modulate the
metabolism of infected cells and limit the infectivity and/or growth of several pathogens. This
review gives an overview of the recent advances in understanding the complexity of the …
pharmacologically activated by high-affinity agonists. LXR activation exerts a combination of
metabolic and anti-inflammatory actions that result in the modulation of immune responses
and in the amelioration of inflammatory disorders. In addition, LXR agonists modulate the
metabolism of infected cells and limit the infectivity and/or growth of several pathogens. This
review gives an overview of the recent advances in understanding the complexity of the …