Inflammation is a hallmark of virtually all liver diseases, such as liver cancer, fibrosis,
nonalcoholic steatohepatitis, alcoholic liver disease, and cholangiopathies. Liver
macrophages have been thoroughly studied in human disease and mouse models,
unravelling that the hepatic mononuclear phagocyte system is more versatile and complex
than previously believed. Liver macrophages mainly consist of liver‐resident phagocytes, or
Kupffer cells (KCs), and bone marrow‐derived recruited monocytes. Although both cell …