Glycogen synthase kinase 3β promotes liver innate immune activation by restraining AMP-activated protein kinase activation
Background & Aims Glycogen synthase kinase 3β (Gsk3β [Gsk3b]) is a ubiquitously
expressed kinase with distinctive functions in different types of cells. Although its roles in
regulating innate immune activation and ischaemia and reperfusion injuries (IRIs) have
been well documented, the underlying mechanisms remain ambiguous, in part because of
the lack of cell-specific tools in vivo. Methods We created a myeloid-specific Gsk3b knockout
(KO) strain to study the function of Gsk3β in macrophages in a murine liver partial warm …
expressed kinase with distinctive functions in different types of cells. Although its roles in
regulating innate immune activation and ischaemia and reperfusion injuries (IRIs) have
been well documented, the underlying mechanisms remain ambiguous, in part because of
the lack of cell-specific tools in vivo. Methods We created a myeloid-specific Gsk3b knockout
(KO) strain to study the function of Gsk3β in macrophages in a murine liver partial warm …