Notch‐triggered maladaptation of liver sinusoidal endothelium aggravates nonalcoholic steatohepatitis through endothelial nitric oxide synthase
ZQ Fang, B Ruan, JJ Liu, JL Duan, ZS Yue, P Song… - Hepatology, 2022 - journals.lww.com
Conclusions Endothelial‐specific Notch activation triggered LSEC maladaptation and
exacerbated NASH phenotypes in an eNOS‐dependent manner. Genetic and
pharmacological inhibition of Notch signaling effectively restored LSEC homeostasis and
ameliorated NASH progression.
exacerbated NASH phenotypes in an eNOS‐dependent manner. Genetic and
pharmacological inhibition of Notch signaling effectively restored LSEC homeostasis and
ameliorated NASH progression.