Myofibroblast YAP/TAZ is dispensable for liver fibrosis in mice
L Xu, N Wettschureck, Y Bai, Z Yuan… - Journal of …, 2021 - journal-of-hepatology.eu
Severe fibrosis often leads to significant mortality as a result of liver failure and cirrhosis.
Recent evidence arising in the Journal of Hepatology etc. shed light on the role of the
mechanosensing Hippo/YAP/TAZ pathway during hepatic fibrosis. 1–5 Those studies
suggested that the YAP/TAZ pathway was activated in various mouse models of liver fibrosis
and in human fibrotic liver. However, conflicting data exist for both positive and negative
regulation of the YAP/TAZ pathway in liver fibrogenesis. The study by Liu et al. elegantly …
Recent evidence arising in the Journal of Hepatology etc. shed light on the role of the
mechanosensing Hippo/YAP/TAZ pathway during hepatic fibrosis. 1–5 Those studies
suggested that the YAP/TAZ pathway was activated in various mouse models of liver fibrosis
and in human fibrotic liver. However, conflicting data exist for both positive and negative
regulation of the YAP/TAZ pathway in liver fibrogenesis. The study by Liu et al. elegantly …