Targeting NFATc4 attenuates non-alcoholic steatohepatitis in mice
M Du, X Wang, L Yuan, B Liu, X Mao, D Huang… - Journal of …, 2020 - Elsevier
Background & Aims The nuclear factor of activated T-cells (NFAT) family was first recognised
to play an important role in the differentiation of T cells, but has since been shown to
regulate multiple pathophysiological processes. However, whether it is involved in the
pathogenesis of non-alcoholic steatohepatitis (NASH) remains unknown. Methods Hepatic
NFATc expression and localisation were analysed in C57BL/6 mice on a methionine–
choline-deficient diet, as well as in samples from non-alcoholic fatty liver disease patients …
to play an important role in the differentiation of T cells, but has since been shown to
regulate multiple pathophysiological processes. However, whether it is involved in the
pathogenesis of non-alcoholic steatohepatitis (NASH) remains unknown. Methods Hepatic
NFATc expression and localisation were analysed in C57BL/6 mice on a methionine–
choline-deficient diet, as well as in samples from non-alcoholic fatty liver disease patients …
