Dysregulation of the ESRP2-NF2-YAP/TAZ axis promotes hepatobiliary carcinogenesis in non-alcoholic fatty liver disease
Background & Aims Non-alcoholic fatty liver disease (NAFLD), the hepatic correlate of the
metabolic syndrome, is a major risk factor for hepatobiliary cancer (HBC). Although chronic
inflammation is thought to be the root cause of all these diseases, the mechanism whereby it
promotes HBC in NAFLD remains poorly understood. Herein, we aim to evaluate the
hypothesis that inflammation-related dysregulation of the ESRP2-NF2-YAP/TAZ axis
promotes HB carcinogenesis. Methods We use murine NAFLD models, liver biopsies from …
metabolic syndrome, is a major risk factor for hepatobiliary cancer (HBC). Although chronic
inflammation is thought to be the root cause of all these diseases, the mechanism whereby it
promotes HBC in NAFLD remains poorly understood. Herein, we aim to evaluate the
hypothesis that inflammation-related dysregulation of the ESRP2-NF2-YAP/TAZ axis
promotes HB carcinogenesis. Methods We use murine NAFLD models, liver biopsies from …
