Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatases in cancer
A Yalcin, S Telang, B Clem, J Chesney - Experimental and molecular …, 2009 - Elsevier
A high rate of glycolytic flux, even in the presence of oxygen, is a central metabolic hallmark
of neoplastic tumors. Cancer cells preferentially utilize glycolysis in order to satisfy their
increased energetic and biosynthetic requirements. This metabolic phenotype has been
confirmed in human studies using positron emission tomography (PET) with 18F-2-fluoro-
deoxy-glucose which have demonstrated that tumors take up 10-fold more glucose than
adjacent normal tissues in vivo. The high glucose metabolism of cancer cells is caused by a …
of neoplastic tumors. Cancer cells preferentially utilize glycolysis in order to satisfy their
increased energetic and biosynthetic requirements. This metabolic phenotype has been
confirmed in human studies using positron emission tomography (PET) with 18F-2-fluoro-
deoxy-glucose which have demonstrated that tumors take up 10-fold more glucose than
adjacent normal tissues in vivo. The high glucose metabolism of cancer cells is caused by a …