Lung transplant recipients with idiopathic pulmonary fibrosis have impaired alloreactive immune responses
P Wang, J Leung, A Lam, S Lee, DR Calabrese… - The Journal of Heart and …, 2022 - Elsevier
Background Telomere dysfunction is associated with idiopathic pulmonary fibrosis (IPF) and
worse outcomes following lung transplantation. Telomere dysfunction may impair immunity
by upregulating p53 and arresting proliferation, but its influence on allograft-specific immune
responses is unknown. We hypothesized that subjects undergoing lung transplantation for
IPF would have impaired T cell proliferation to donor antigens. Methods We analyzed
peripheral blood mononuclear cells (PBMC) from 14 IPF lung transplant recipients and 12 …
worse outcomes following lung transplantation. Telomere dysfunction may impair immunity
by upregulating p53 and arresting proliferation, but its influence on allograft-specific immune
responses is unknown. We hypothesized that subjects undergoing lung transplantation for
IPF would have impaired T cell proliferation to donor antigens. Methods We analyzed
peripheral blood mononuclear cells (PBMC) from 14 IPF lung transplant recipients and 12 …