A new classification system for chronic lung allograft dysfunction

GM Verleden, G Raghu, KC Meyer, AR Glanville… - The Journal of Heart and …, 2014 - Elsevier
Although survival after lung transplantation has improved significantly during the last
decade, chronic rejection is thought to be the major cause of late mortality. The physiologic
hallmark of chronic rejection has been a persistent fall in forced expiratory volume in 1
second associated with an obstructive ventilatory defect, for which the term bronchiolitis
obliterans syndrome (BOS) was defined to allow a uniformity of description and grading of
severity throughout the world. Although BOS was generally thought to be irreversible, recent …