[HTML][HTML] Mitochondrial damage–associated molecular patterns released by lung transplants are associated with primary graft dysfunction
D Scozzi, M Ibrahim, F Liao, X Lin, HM Hsiao… - American Journal of …, 2019 - Elsevier
Primary graft dysfunction (PGD) is a major limitation in short-and long-term lung transplant
survival. Recent work has shown that mitochondrial damage–associated molecular patterns
(mtDAMPs) can promote solid organ injury, but whether they contribute to PGD severity
remains unclear. We quantitated circulating plasma mitochondrial DNA (mtDNA) in 62
patients, before lung transplantation and shortly after arrival to the intensive care unit.
Although all recipients released mtDNA, high levels were associated with severe PGD …
survival. Recent work has shown that mitochondrial damage–associated molecular patterns
(mtDAMPs) can promote solid organ injury, but whether they contribute to PGD severity
remains unclear. We quantitated circulating plasma mitochondrial DNA (mtDNA) in 62
patients, before lung transplantation and shortly after arrival to the intensive care unit.
Although all recipients released mtDNA, high levels were associated with severe PGD …
