The effect of renal ischemia-reperfusion injury on expression of RAE-1 and H60 in mice kidney
L Feng, F Cheng, Z Ye, S Li, Y He, X Yao… - Transplantation …, 2006 - Elsevier
INTRODUCTION: NKG2D, an activating receptor, may trigger NK and CD8+ T cells. Ligands
for NKG2D and major histocompability complex class I chain-related antigen (MIC) have
been reported to be expressed in rejected human renal allografts. MIC-NKG2D engagement
may induce natural killer (NK) cell activation providing T-cell costimulation. We hypothesized
that this interaction between innate and adaptive immunity may occur during kidney
ischemia-reperfusion injury (IRI). METHODS: Male C57BL/6 mice after right renal resection …
for NKG2D and major histocompability complex class I chain-related antigen (MIC) have
been reported to be expressed in rejected human renal allografts. MIC-NKG2D engagement
may induce natural killer (NK) cell activation providing T-cell costimulation. We hypothesized
that this interaction between innate and adaptive immunity may occur during kidney
ischemia-reperfusion injury (IRI). METHODS: Male C57BL/6 mice after right renal resection …
