Cellular senescence in development, regeneration and disease

M Rhinn, B Ritschka, WM Keyes - Development, 2019 - journals.biologists.com
Development, 2019journals.biologists.com
Cellular senescence is a state comprising an essentially irreversible proliferative arrest
combined with phenotypic changes and pronounced secretory activity. Although
senescence has long been linked with aging, recent studies have uncovered functional
roles for senescence in embryonic development, regeneration and reprogramming, and
have helped to advance our understanding of this process as a highly coordinated and
programmed cellular state. In this Primer article, we summarize some of the key findings in …
Abstract
Cellular senescence is a state comprising an essentially irreversible proliferative arrest combined with phenotypic changes and pronounced secretory activity. Although senescence has long been linked with aging, recent studies have uncovered functional roles for senescence in embryonic development, regeneration and reprogramming, and have helped to advance our understanding of this process as a highly coordinated and programmed cellular state. In this Primer article, we summarize some of the key findings in the field and attempt to explain them in a simple model that reconciles the normal and pathological roles for senescence. We discuss how a primary role of cellular senescence is to contribute to normal development, cell plasticity and tissue repair, as a dynamic and tightly regulated cellular program. However, when this process is perturbed, the beneficial effects turn detrimental and can contribute to disease and aging.
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