Radiation-induced DNA repair foci: spatio-temporal aspects of formation, application for assessment of radiosensitivity and biological dosimetry
IY Belyaev - Mutation Research/Reviews in Mutation Research, 2010 - Elsevier
Several proteins involved in DNA repair and DNA damage signaling have been shown to
produce discrete foci in response to ionizing radiation. These foci are believed to co-localize
to DSB and referred to as ionizing radiation-induced foci (IRIF) or DNA repair foci. Recent
studies have revealed that some residual IRIF remain in cells for a relatively long time after
irradiation, and have indicated a possible correlation between radiosensitivity of cells and
residual IRIF. Remarkably, residual foci are significantly larger in size than the initial foci …
produce discrete foci in response to ionizing radiation. These foci are believed to co-localize
to DSB and referred to as ionizing radiation-induced foci (IRIF) or DNA repair foci. Recent
studies have revealed that some residual IRIF remain in cells for a relatively long time after
irradiation, and have indicated a possible correlation between radiosensitivity of cells and
residual IRIF. Remarkably, residual foci are significantly larger in size than the initial foci …