IgE, mast cells, basophils, and eosinophils are essential components of allergic
inflammation. Antigen-specific IgE production, with subsequent fixation of IgE to FcεRI
receptors on mast cells and basophils, is central to the initiation and propagation of
immediate hypersensitivity reactions. Mast cells, basophils, and eosinophils are central
effector cells in allergic inflammation, as well as in innate and adaptive immunity. This
review highlights what is known about these components and their roles in disease …