The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver
G Hellgren, JO Jansson, LMS Carlsson… - Growth Hormone & IGF …, 1999 - Elsevier
Studies in cell lines have shown that Jak2 is the primary tyrosine kinase involved in signal
transduction by the growth hormone receptor (GHR). In addition, growth hormone (GH)
stimulates tyrosine phosphorylation of Jak1 and Jak3 in certain cell lines, while the effect on
Tyk2 has not been analysed. We have investigated the expression of Jak proteins in human
liver and analysed their interactions with the GHR. Using Western blot analysis and
immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in …
transduction by the growth hormone receptor (GHR). In addition, growth hormone (GH)
stimulates tyrosine phosphorylation of Jak1 and Jak3 in certain cell lines, while the effect on
Tyk2 has not been analysed. We have investigated the expression of Jak proteins in human
liver and analysed their interactions with the GHR. Using Western blot analysis and
immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in …